KLF4 (PT0167R) PT™ Rabbit mAb
-YM8101
主要信息
Target
KLF4
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IHC, IF, ELISA
MW
55kD (Calculated)
60kD (Observed)
Conjugate/Modification
Unmodified
货号: YM8101
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
IHC 1:200-1000; WB 1:1000-5000; IF 1:200-1000; ELISA 1:5000-20000
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year (Do not lower than -25°C)
理论分子量
55kD
实测条带
60kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0167R
同种型
IgG, Kappa
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抗原&靶点信息
免疫原:
The specific immunogen used to produce this antibody is proprietary information.
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特异性:
Endogenous
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基因名称:
KLF4
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蛋白名称:
Krueppel-like factor 4
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别名:
KLF4 ;
EZF ;
GKLF ;
Krueppel-like factor 4 ;
Epithelial zinc finger protein EZF ;
Gut-enriched krueppel-like factor
EZF ;
GKLF ;
Krueppel-like factor 4 ;
Epithelial zinc finger protein EZF ;
Gut-enriched krueppel-like factor
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背景:
This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly , and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq , Sep 2015] ,
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功能:
Function:Transcription factor which acts as both an activator and repressor. Binds the CACCC core sequence. Binds to multiple sites in the 5'-flanking region of its own gene and can activate its own transcription. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. ,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family. ,similarity:Contains 3 C2H2-type zinc fingers. ,subunit:Interaction with the C-terminal domain of MUC1 enhances suppression of TP53/p53 transcription. ,
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细胞定位:
Nuclear
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研究领域:
>>Signaling pathways regulating pluripotency of stem cells ;
>>Chemical carcinogenesis - receptor activation
>>Chemical carcinogenesis - receptor activation
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文献引用（{{totalcount}}）
货号: YM8101
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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