PRAS40 (PT0562R) PT™ Rabbit mAb
-YM8378
主要信息
Target
PRAS40
Host Species
Rabbit
Reactivity
Human, Mouse, Rat
Applications
WB, IF, IP, ELISA
MW
27kD (Calculated)
40kD (Observed)
Conjugate/Modification
Unmodified
货号: YM8378
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
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详细信息
推荐稀释比
WB 1:2000-1:10000; IF 1:200-1:1000; ELISA 1:5000-1:20000; IP 1:50-1:200;
组成
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
特异性
Endogenous
纯化工艺
Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
储存
-15°C to -25°C/1 year(Do not lower than -25°C)
理论分子量
27kD
实测条带
40kD
修饰
Unmodified
克隆性
Monoclonal
克隆号
PT0562R
同种型
IgG,Kappa
相关产品
Primary Antibodies
PRAS40 Rabbit pAb
YT3850
预览→
Primary Antibodies
PRAS40 (Phospho Thr246) Rabbit pAb
YP0302
预览→
ELISA Kits
Total PRAS40 Cell-Based Colorimetric ELISA Kit
KA3016C
预览→
ELISA Kits
Akt1 S1 (Phospho Thr246) Cell-Based Colorimetric ELISA Kit
KA1267C
预览→
抗原&靶点信息
特异性:
Endogenous
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基因名称:
AKT1S1
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蛋白名称:
Proline-rich AKT1 substrate 1
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别名:
AKT1S1 ;
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
PRAS40 ;
Proline-rich AKT1 substrate 1 ;
40 kDa proline-rich AKT substrate
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背景:
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008],
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功能:
Function:May play an important role in phosphatidylinositol 3-kinase (PI3K)-AKT1 survival signaling. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. Its role in survival signaling pathways may be modulated by oxidative stress. May also play a role in nerve growth factor-mediated neuroprotection.,subcellular location:Found in the cytosolic fraction of the brain.,subunit:The phosphorylated form interacts with 14-3-3.,tissue specificity:Widely expressed with highest levels of expression in liver and heart. Expressed at higher levels in cancer cell lines (e.g. A549 and HeLa) than in normal cell lines (e.g. HEK293).,
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细胞定位:
Cytoplasm
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研究领域:
>>Autophagy - animal ;
>>mTOR signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Thermogenesis ;
>>Shigellosis
>>mTOR signaling pathway ;
>>AMPK signaling pathway ;
>>Longevity regulating pathway ;
>>Longevity regulating pathway - multiple species ;
>>Thermogenesis ;
>>Shigellosis
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信号通路
Cellular Processes >> Transport and catabolism >> Autophagy - animal
Organismal Systems >> Aging >> Longevity regulating pathway
Organismal Systems >> Aging >> Longevity regulating pathway - multiple species
Environmental Information Processing >> Signal transduction >> AMPK signaling pathway
Environmental Information Processing >> Signal transduction >> mTOR signaling pathway
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货号: YM8378
规格
价格
货期
数量
200μL
￥3,580.00
现货
0
100μL
￥1,960.00
现货
0
40μL
￥960.00
现货
0
加入购物车
已收藏
收藏
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